2017
| June | ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice | SCIENCE | Loss of ELABELA, a placental hormone, triggers preeclampsia with hypertension, proteinuria, and IUGR. This can be corrected by infusion of synthetic ELA. ELA knockout mice embryos have severe but incompletely penetrant cardiovascular defects. |
| June | Structural Basis for Apelin Control of the Human Apelin Receptor | STRUCTURE | The crystal structure of APLNR in complex with an APELIN mimetic agonist is revealed. Endogenous peptide ligands of APLNR such as ELA may have a high degree of conformational flexibility to modulate receptor activation via a two site binding mechanism. |
2016
| April | The Apelin receptor enhances Nodal/TGFbeta signaling to ensure proper cardiac development | eLIFE | Loss of Aplnr in zebrafish dampens Nodal/Tgfbeta signalling during mesendoderm development. Elevating Nodal is sufficient to rescue heart development in Aplnr mutant embryos. |
| March | Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions | JOURNAL OF MEDICINAL CHEMISTRY | This is the first report of an analogue of ELA consisting its the last carboxy 13 residues. This C-terminal fragment is shown to be critical for binding to APLNR and downstream signalling. When administered to rats this analogue displays potent inotropic and hypotensive properties. This highlights the potential therapeutic use of ELA for managing cardiovascular diseases. |
2015
| October | ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal Via the PI3K/AKT Pathway | CELL STEM CELL | ELABELA is an endogenous pro-survival growth factor secreted by hESCs. It is required for self-renewal and maintenance of pluripotency. It signals in a paracrine manner, independently of APLNR, via the PI3K/AKT pathway. |
| July | ELABELA Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling | JOURNAL BIOLOGICAL CHEMISTRY | ELABELA is co-expressed with APLNR in adult kidney where it may control fluid homoeostasis. Injection of synthetic ELA is sufficient to increases diuresis and water intake in rats. |
| June | An Elabela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells | CELL STEM CELL | In murine ES cells, the Elabela mRNA inhibits the activity of Hnrnpl via direct binding. This Ela non-coding function serves to increase Tp53-mediated damaged-induced apoptosis. |
| May | The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis | eLIFE | In zebrafish, Elabela and Apelin expressed in the midline guide Aplnra/b-expressing angioblasts for proper vasculogenesis. |
2014
| January |
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SCIENCE | Independent confirmation of ELABELA's identity, knockout and activity on Aplnr receptors in zebrafish |
2013
| December |
ELABELA: A Hormone Essential for Heart Development Signals via the Apelin Receptor |
DEVELOPMENTAL CELL | Discovery of the hormone ELABELA, its loss-of-function phenotype in zebrafish and its cognate receptor APLNR. |
2010
| February |
Expression of two novel transcripts in the mouse definitive endoderm | GENE EXPRESSION PATTERN | Spatial and temporal expression of ELABELA transcripts in mouse embryos |
2007
| March |
The G Protein-Coupled Receptor Agtrl1b Regulates Early Development of Myocardial Progenitors | DEVELOPMENTAL CELL | Aplnrb mutation in zebrafish phenocopies loss of ELABELA |
| March | Apelin and Its Receptor Control Heart Field Formation during Zebrafish Gastrulation | DEVELOPMENTAL CELL | Aplnr depletion in zebrafish phenocopies loss of ELABELA |